Now showing items 1-6 of 6
Investigation of Prestin Membrane Topology by Substituted Cysteine Accessibility Method.
(Creighton University, 2008-04-23)
Prestin, an integral membrane motor protein in the outer hair cells of the inner ear, is proposed to be crucial for cochlear amplification. In support of this, in prestin knock out mice, there is a 40-60 dB loss of hearing ...
MicroRNAs are essential for hair cell development.
(Creighton University, 2008-10-10)
MicroRNAs are small non-coding RNAs that are processed through an endogenous biological pathway and function to post-transcriptionally regulate target gene expression. MicroRNAs affect cellular proliferation, differentiation, ...
Leukemia/Lymphoma Related Factor in Human Prostate Carcinoma
(Creighton University, 2008-05)
Benign prostatic hyperplasia (BPH) and prostate cancer (PC) are critical health problems in elderly population with PC being the most common non-dermatologic malignancy in men. Although epidermal growth factor (EGF) plays ...
Erbb2: A Regulator of the Skin's Response to Ultraviolet Radiation
(Creighton University, 2008-05-20)
Non-melanoma skin cancer is the most commonly diagnosed cancer in the United States. The cause of most non-melanoma skin cancer is prolonged exposure to UVirradiation. UV-irradiation acts as both an initiator and tumor ...
Importance of the Gastrin N-Terminal Region in Binding and Activation of the Putative G17-Gly Receptor on Human Colonic Carcinoma Cells
(Creighton University, 2008-05-05)
The contribution of the N-terminal region of gastrin-17 (G17) to the binding and activation of the putative gastrin processing intermediate receptor(s) on human colorectal cancer cells is investigated. The C-terminal ...
Expression of Leukemia/Lymphoma Related Factor (LRF) in Human Breast Carcinoma
(Creighton University, 2008-08)
The pox-virus zinc finger protein (POZ-ZF), also termed leukemia/lymphoma related factor (LRF) belongs to the POK family of transcriptional repressors, which is also known as POK erythroid myeloid ontogenic factor (Pokemon), ...