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Investigation of The Role of Aromatic-Backbone Amide Interactions in Peptide and Protein Structure
(Creighton University, 2001)
The delicate balance of noncovalent interactions determines the three dimensional structure of peptides and proteins. These interactions include hydrogen bonds, salt bridges, weakly polar interactions and the hydrophobic ...
The Effect of Cu2+-Induced Oxidation on the Secondary Structure of A-Acetyl Amyloid-|3(25-35) Peptide Amide
(Creighton University, 2007-05-03)
Amyloid beta peptide (A(3) is cleaved from the amyloid precursor protein (APP) by P and y secretases and is thought to be responsible for the neurodegeneration that causes the dementia and memory loss observed in Alzheimer's ...
Importance of the Gastrin N-Terminal Region in Binding and Activation of the Putative G17-Gly Receptor on Human Colonic Carcinoma Cells
(Creighton University, 2008-05-05)
The contribution of the N-terminal region of gastrin-17 (G17) to the binding and activation of the putative gastrin processing intermediate receptor(s) on human colorectal cancer cells is investigated. The C-terminal ...