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dc.contributor.advisorTolman, Justin A.en_US
dc.contributor.authorWani, Rajvi Jayant Nitaen_US
dc.date.accessioned2014-08-21T17:59:14Z
dc.date.available2016-08-26T08:40:39Z
dc.date.issued2014-08-06en_US
dc.identifier.urihttp://hdl.handle.net/10504/62832
dc.description.abstractSpray drying is an extensively used technique for particle size reduction of many pharmaceutical and non-pharmaceutical products. BÜchi Corporation manufactures two spray dryers for lab-scale production of spray dried product called Mini Spray Dryer B-290 and Nano Spray Dryer B-90. While the B-290 is able to generate microparticles, the B-90 claims to produce nanoparticles. The aim of this project was to design a novel nozzle that can aid in production of nanoparticles when incorporated in B-290 and eliminating the need to invest in and operate a separate spray dryer to produce nano-particles. A nano-nozzle was created using the Aeroneb® Solo, a modified commercial nebulizer, which contains a vibrating plate enabled to produce nanoparticles. Incorporation of the nano-nozzle in B-290 was found to be comparatively user-friendly and offers a solution to the problems encountered on the use of B-90.|To gauge the functioning of nano-nozzle and provide proof to the concept, three excipients, lactose, hydroxypropyl cellulose and polyvinyl alcohol, were spray dried using nano-nozzle. Aqueous or hydroalcoholic solutions of the excipients were prepared and spray dried using the nano-nozzle incorporated in the B-290 and the product obtained was compared with that obtained using the conventional nozzle in B-290 and B-90.|The obtained yield of spherical particles in de-agglomerated and free-flowing was found to be higher using the nano-nozzle in the B-290 as opposed to the conventional nozzle in B-290 and B- 90. The particle size distribution showed no significant difference (p<0.05) between the use of the nano-nozzle and B-90, with mean particle sizes ranging from 300-500 nm. Also, surface morphology was similar between the powders spray dried using B-90 and nano-nozzle. The physical state characteristics remained unchanged (as seen in Differential Scanning Calorimetry results) and the chemical entity of the excipients remained unaffected (results from Fourier Transform Infra-red Spectroscopy) on using the two fluid nozzle of the Mini spray dryer B-290, nozzle of the Nano spray dryer and nano-nozzle. Use of nano-nozzle in a B-290 is a substitute to the B-90 for spray drying to produce nanoparticles. Additional investigations are necessary for potential use in laboratory scale or industrial generation of nanoparticles.en_US
dc.language.isoen_USen_US
dc.publisherCreighton Universityen_US
dc.rightsCopyright is retained by the Author. A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above.en_US
dc.subject.meshDrug Delivery Systemsen_US
dc.subject.meshNanoparticles--chemistryen_US
dc.subject.meshPharmaceutical Vehiclesen_US
dc.titleProduction of nanoparticles through a modified mini spray dryer B-290 using a nano-nozzleen_US
dc.typeThesis
dc.rights.holderWani Rajvien_US
dc.publisher.locationOmaha, Nebraskaen_US
dc.description.noteProQuest Traditional Publishing Optionen_US
dc.description.pagesxvii, 74 pagesen_US
dc.contributor.cuauthorWani, Rajvi Jayant Nitaen_US
dc.embargo.terms2016-08-21
dc.degree.levelMS (Master of Science)en_US
dc.degree.disciplinePharmaceutical Science (graduate program)en_US
dc.degree.nameM.S. in Pharmaceutical Sciencesen_US
dc.degree.grantorGraduate Schoolen_US
dc.degree.committeeSingh, Somnathen_US
dc.degree.committeeChauhan, Harshen_US


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