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dc.contributor.advisorAgrawal, Devendra K.en_US
dc.contributor.authorRoberts, John Mose Jr.en_US
dc.date.accessioned2014-12-08T22:38:55Z
dc.date.available2014-12-08T22:38:55Z
dc.date.issued2003en_US
dc.identifier.urihttp://hdl.handle.net/10504/64800
dc.description.abstractBradykinin, following activation of the Kinin-Kallikrein cascade in acute spinal cord injury (ASCI), acts on the B2 receptors of blood vessels and neurons causing vasogenic edema, inflammation and neuronal death. This study explores the effect of CP0597, a B2 bradykinin receptor antagonist, and B9430, a B2/B1 bradykinin receptor antagonist on functional outcome following impact injury in an adult rat ASCI model. A randomized double blind placebo controlled study of selective Bradykinin receptor antagonists was performed on 99 male Sprague-Dawley rats (500 g) in experimental ACSI. A moderate ASCI was created using a dropped weight technique (NYU-SCI) following laminectomy at the T12 level (n=99). CP-0597 (300ng/kg/min for 7 days), B9430 (35ng/kg/min for 7 days) or placebo was administered using an osmotic pump. Functional outcome was determined by the Tarlov’s scores, Inclined Plane ability and Opto-Varimex 3D activity at 28 days postinjury. All animals underwent significant improvement from baseline. Although mean scores for all three groups were similar, CP-0597 exhibited the greater mean percentage improvement in ambulation from day 1 baseline [CP-0597 - 813%, B9430 - 671%, placebo - 366%, p = 0.0356]. This suggests that the B2 bradykinin receptor antagonist is more effective than the B2/B1 bradykinin receptor antagonist in improving independent ambulation following ASCI. Therefore, B2 bradykinin receptor antagonists may be a possible therapeutic role for these agents following ACSI.en_US
dc.language.isoen_USen_US
dc.publisherCreighton Universityen_US
dc.rightsCopyright is retained by the Author. A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above.en_US
dc.subject.meshBradykininen_US
dc.subject.meshRatsen_US
dc.subject.meshReceptor, Bradykinin B2--agonistsen_US
dc.titleThe Role of Bradykinin Antagonists in Experimental Acute Spinal Cord Injuryen_US
dc.typeThesis
dc.rights.holderJohn Mose Roberts Jr.en_US
dc.publisher.locationOmaha, Nebraskaen_US
dc.description.noteProQuest Traditional Publishing Optionen_US
dc.description.pagesxix, 238 pagesen_US
dc.contributor.cuauthorRoberts, John Mose Jr.en_US
dc.degree.levelMS (Master of Science)en_US
dc.degree.disciplineBiomedical Sciences (graduate program)en_US
dc.degree.nameM.S. in Biomedical Sciencesen_US
dc.degree.grantorGraduate Schoolen_US
dc.degree.committeeNarotam, Pradeep K.en_US
dc.degree.committeeNichols, David H.en_US
dc.degree.committeeQuinn, Thomas H.en_US


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