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dc.contributor.advisorFritzsch, Bernden_US
dc.contributor.authorPauley, Sarahen_US
dc.date.accessioned2014-12-23T15:25:21Z
dc.date.available2014-12-23T15:25:21Z
dc.date.issued2006en_US
dc.identifier.urihttp://hdl.handle.net/10504/65392
dc.description.abstract(First paragraph) Hearing loss is a condition affecting people of all ages and can be categorized as either conductive or sensorineural. Conductive hearing loss is caused by pathology of the middle ear and will not be addressed in this volume. Our focus here is on sensorineural hearing loss, or hearing loss caused by pathology of the inner ear. Sensorineural hearing loss can be either inherited or acguired and congenital or late onset. Over 400 syndromes have been described that demonstrate hearing loss along with a variety of other anomalies. A few of the most common hereditary hearing loss syndromes include Branchi- oto-renal (caused by mutations in Eya1 and Six1), Waardenburg’s (mutations occur in the Pax3 and MITF genes, among others), Pendred's (caused by a mutation in the PDS /pendrin gene) and Usher’s (caused by a mutation in one of several USH genes) Syndromes. In addition, over 70 different genes have been described that produce non-syndromic hearing loss. These genes code for a variety of protein products including structural proteins, ion channels, and transcription factors. Acguired sensorineural hearing loss can be caused by trauma to the inner ear, environmental auditory insults, ototoxic medications and idiopathic sudden sensorineural hearing loss, and presbyacusis (hearing loss in elderly patients). The vestibular portion of the inner ear is also susceptible to disease including Meniere's disease, vestibular neuronitis, and benign paroxysmal positional vertigo (Snow, 2003).en_US
dc.language.isoen_USen_US
dc.publisherCreighton Universityen_US
dc.rightsCopyright is retained by the Author. A non-exclusive distribution right is granted to Creighton University and to ProQuest following the publishing model selected above.en_US
dc.subject.meshEar, Inner--embryologyen_US
dc.subject.meshFibroblast Growth Factors--geneticsen_US
dc.titleDevelopment of the Inner Ear: a Molecular, Cellular and Evolutionary Approach to Understanding the Development of the Inner Ear with an Emphasis on the Roles of Fgf10 and Foxglen_US
dc.typeDissertation
dc.rights.holderSarah Pauleyen_US
dc.publisher.locationOmaha, Nebraskaen_US
dc.description.noteProQuest Traditional Publishing Optionen_US
dc.description.pagesiii, 156 pagesen_US
dc.contributor.cuauthorPauley, Sarahen_US
dc.degree.levelPhD (Doctor of Philosophy)en_US
dc.degree.disciplineBiomedical Sciences (graduate program)en_US
dc.degree.namePh.D. in Biomedical Sciencesen_US
dc.degree.grantorGraduate Schoolen_US


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